Table 3 A summary of the descriptive characteristics of the included studies (N = 6)
Author, year, country | Study design | Subjects: (participants/age/tooth type) | Restoration | Follow-up (month) | Intervention group | Control group | Conclusions | |||
|---|---|---|---|---|---|---|---|---|---|---|
Type (ratio/placement) | Success rate | Type | Success rate | |||||||
Nakornchai et al Thailand 2010 [16] | RCT | 37 children 3–8 years 50 primary molars | GIC Stainless steel crowns (same visit) | 6 12 | 3 Mix-MP: Ciprofloxacin Metronidazole Minocycline 1:1:1/root canal entrance 2.5% NaOCl | Overall Clinical: 6 months: 100% 12 months: 96% Radiographic: 6 months: 84% 12 months: 76% | Vitapex K files 2.5% NaOCl | Clinical: 6 months: 100% 12 months:96% Radiographic: 6 months: 80% 12 months: 56% | Clinical success at 12 months: no statistically significant difference between the two groups (P > 0.005). Radiographic success at 12 months: no statistically significant difference between the two groups (P > 0.005) | |
Agarwal et al India 2011 [17] | RCT | 34 children 4–9 years 40 primary molars | GIC Stainless steel crowns (after 24 h) | 1 3 6 12 | 3 Mix-MP: Ciprofloxacin Metronidazole Cefixime 1:1:1/root canal entrance Normal saline | Overall: Nm 6 months: 38.89% 12 months: 33.33% | Zinc oxide eugenol cement H files 5% NAOCl | Overall: 78.5% 6 months: 92.86% 12 months: 78.57% | A significant difference in the proportion of failure/success among the groups (p = 0.016) | |
Daher et al Brazil 2015 [18] | RCT | 36 children 3–10 (6.2 ± 1.5) years 53 primary molars | GIC + Composite restoration | 1 3 6 12, 18, 24/until exfoliation | CTZ paste: Chloramphenicol Tetracycline, Zinc oxide-eugenol 1:1:2/radicular pulp stumps | Overall: 27% | Calcium hydroxide paste (Calcium hydroxide, zinc oxide, propylene glycol) K-files 1% NaOCL | Overall: 68.7% | Low survival rate of NIET in a 2-year follow-up (P = 0.02); The radiographic ineffectiveness discourages its use instead of conventional root canal treatment | |
Doneria et al India 2017 [19] | RCT | 43 children 4–8 years 64 primary molars | GIC (same visit) Stainless steel crowns (after 15 days) | 6 12 | 3 Mix-MP: Ornidazole Ciprofloxacin Cefaclor 1:1:1/medication cavity 1% NaOCL | Clinical: 6 months: 95.5% 12 months: 95.5% Radiographic 6 months: 83.5% 12 months: 79.2% | ZnO–OO H Files 1% NaOCL /saline | Clinical: 6 months: 100% 12 months: 100% Radiographic 6 months: 100% 12 months: 100% | Clinical success at 12 months: no statistically significant difference between the two groups (P = 0.429). Radiographic success at 12 months: a statistically significant difference between the two groups (P = 0.011): Internal resorption was observed in three teeth treated with modified 3 Mix‑MP paste | |
Vitapex H Files 1% NaOCL + saline | Clinical: 6 months: 100% 12 months: 100% Radiographic 6 months: 100% 12 months:100% | |||||||||
Zacharczuk et al Argentina 2019 [21] | RCT | 46 children 6.15 ± 1.38 years 6.3 ± 1.49 years 46 primary molars | ZOE Stainless steel (after 7 days) | 1 3 6 12 18 | 3 Mix-MP: Ciprofloxacin Metronidazole Minocycline 1:1:1/Nm 2.5% NaOCL | Clinical: 6 months: 90% 12 months: 83.3% 18 months: 82.3% Overall: 87.5% Radiographic: 6 months: 80% 12 months:77.7% 18 months:76.4% Overall: 82% | Maisto-Capurro paste K Files 1% NaOCL | Clinical 6 months: 89.4% 12 months: 88.8% 18 months: 88.8 Overall: 91.5% Radiographic: 6 months 84.2% 12 months: 83.3% 18 months: 83.3% Overall: 88.3% | No significant clinical or radiographic difference between groups (P = 0.48, 031) Both treatments showed similar clinical and radiographic results during the study periods | |
Divya et al India 2019 [20] | RCT | 17 children 4–9 years 30 primary molars | GIC Stainless steel crowns (Same visit) | 3 6 12 | 3 Mix MP: Ciprofloxacin Metronidazole Minocycline 1:3:3:/pulp chamber floor 3% NaOCL | Clinical: 6 months: 100% 12 months: 93% Radiographic: 6 months: 20% 12 months: 60% Overall: 60% | Propolis liquid-mixed Endoflas powder mixture (2:1) K Files 3% NaOCL/Saline | Clinical: 6 months: 100% 12 months: 100% Overall: 100% Radiographic: 6 months: 40% 12 months: 100% Overall: 100% | Propolis liquid mixed Endoflas powder combination showed better results than NIET The difference in the radiograph success rate between the two groups was statistically significant (p < 0.05) | |